WCN23-1048 PI3K-Akt-mTOR PATHWAY REGULATES PERICYTE-MYOFIBROBLAST TRANSITION THROUGH REGULATING HKII
نویسندگان
چکیده
An increasing number of comprehensive genetic fate mapping studies have demonstrated that pericytes are the main progenitors renal scar-forming myofibroblasts, and contribute in poor repair acute kidney injury progression to chronic disease. Following unilateral ureteral obstruction, injured epithelial cells primarily secreted TGF-β1, which could then trigger pericyte-myofibroblast transition (PMT). Studies found a novel link between metabolism epigenetic modulation transdifferentiation, metabolites can regulate differentiation.
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2023
ISSN: ['2468-0249']
DOI: https://doi.org/10.1016/j.ekir.2023.02.514